OBJECTIVE: To investigate the immunoregulation of dendritic cells in allergic rhinitis. METHOD: Adopting the cell culture and the enzyme linked immunosorbant assay to examine the patients' Th1/Th2 in the blood. Observing that how is the DC's function in immunoregulation of allergic rhinitis. RESULT: The concentration of the IFN-gamma advanced obviously in post-stimulatory supernatant liquid after using the mature DC. CONCLUSION: The mature dendritic cells can polarize naive T-cells into Th1 effector cells, and are recognized as having a central role in the establishment of T-cell memory and peripheral immune tolerance. DC could be exploited as targets for therapy in asthma and allergic rhinitis.