Two-photon molecular excitation imaging of Ca2+ transients in Langendorff-perfused mouse hearts.

Journal Article (Journal Article)

The ability to image calcium signals at subcellular levels within the intact depolarizing heart could provide valuable information toward a more integrated understanding of cardiac function. Accordingly, a system combining two-photon excitation with laser-scanning microscopy was developed to monitor electrically evoked [Ca(2+)](i) transients in individual cardiomyocytes within noncontracting Langendorff-perfused mouse hearts. [Ca(2+)](i) transients were recorded at depths

Full Text

Duke Authors

Cited Authors

  • Rubart, M; Wang, E; Dunn, KW; Field, LJ

Published Date

  • June 2003

Published In

Volume / Issue

  • 284 / 6

Start / End Page

  • C1654 - C1668

PubMed ID

  • 12584115

International Standard Serial Number (ISSN)

  • 0363-6143

Digital Object Identifier (DOI)

  • 10.1152/ajpcell.00469.2002


  • eng

Conference Location

  • United States