The Cushing Response: a case for a review of its role as a physiological reflex.

Journal Article (Journal Article;Review)

Despite a century of work on the subject, controversy still exists as to the physiological relevance of the Cushing response (CR), a state of raised systemic blood pressure and bradycardia associated with raised intracranial pressure. The alternative that has been proposed to the classical belief of pre-terminal brainstem damage is of a baroreflex that attempts to maintain cerebral perfusion in response to situations of extreme elevations in intracranial pressure or brainstem ischemia. We report a patient with spontaneous subarachnoid haemorrhage who demonstrated CR, which was later seen to self-abort with an eventual good outcome. We review the existing literature and propose that our clinical case may provide further support for a physiological role of CR.

Full Text

Duke Authors

Cited Authors

  • Wan, WH; Ang, BT; Wang, E

Published Date

  • March 2008

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 223 - 228

PubMed ID

  • 18182296

International Standard Serial Number (ISSN)

  • 0967-5868

Digital Object Identifier (DOI)

  • 10.1016/j.jocn.2007.05.025


  • eng

Conference Location

  • Scotland