Synthesis and evaluation of compounds that facilitate the gastrointestinal absorption of heparin.


Journal Article

A family of novel compounds (delivery agents) that promote the gastrointestinal absorption of USP heparin in rats and primates has been discovered. The delivery agents in combination with heparin were administered either orally or intracolonically in an aqueous propylene glycol solution and caused dramatic increases in both plasma heparin concentrations (anti-Factor Xa) and clotting times (APTT). Using one of the most effective delivery agents in this series, an estimated relative bioavailability of 8% can be achieved following oral administration to cynomolgus monkeys. To establish a correlation between the in vivo data and an in vitro parameter, immobilized artificial membrane (IAM) chromatography was performed. Log relative k' values were correlated to the efficiency of oral heparin delivery.

Full Text

Duke Authors

Cited Authors

  • Leone-Bay, A; Paton, DR; Freeman, J; Lercara, C; O'Toole, D; Gschneidner, D; Wang, E; Harris, E; Rosado, C; Rivera, T; DeVincent, A; Tai, M; Mercogliano, F; Agarwal, R; Leipold, H; Baughman, RA

Published Date

  • March 26, 1998

Published In

Volume / Issue

  • 41 / 7

Start / End Page

  • 1163 - 1171

PubMed ID

  • 9544216

Pubmed Central ID

  • 9544216

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm970811m


  • eng

Conference Location

  • United States