Discrete wavelets transform for signal denoising in capillary electrophoresis with electrochemiluminescence detection.

Journal Article (Journal Article)

Discrete wavelets transform (DWT) was applied to noise on removal capillary electrophoresis-electrochemiluminescence (CE-ECL) electropherograms. Several typical wavelet transforms, including Haar, Daublets, Coiflets, and Symmlets, were evaluated. Four types of determining threshold methods, fixed form threshold, rigorous Stein's unbiased estimate of risk (rigorous SURE), heuristic SURE and minimax, combined with hard and soft thresholding methods were compared. The denoising study on synthetic signals showed that wave Symmlet 4 with a level decomposition of 5 and the thresholding method of heuristic SURE-hard provide the optimum denoising strategy. Using this strategy, the noise on CE-ECL electropherograms could be removed adequately. Compared with the Savitzky-Golay and Fourier transform denoising methods, DWT is an efficient method for noise removal with a better preservation of the shape of peaks.

Full Text

Duke Authors

Cited Authors

  • Cao, W; Chen, X; Yang, X; Wang, E

Published Date

  • September 2003

Published In

Volume / Issue

  • 24 / 18

Start / End Page

  • 3124 - 3130

PubMed ID

  • 14518034

International Standard Serial Number (ISSN)

  • 0173-0835

Digital Object Identifier (DOI)

  • 10.1002/elps.200305556


  • eng

Conference Location

  • Germany