MicroRNA regulation and interspecific variation of gene expression.


Journal Article

MicroRNAs (miRNAs) modulate expression of their target genes in various tissues and at different developmental stages, but it is unclear whether they drive cross-species variation in gene expression. By comparing data from mammal and fly species we found that the cross-species expression variation of miRNA targets is significantly lower than that of other genes. This implies that miRNAs can affect gene expression by reducing stochastic noise, buffering cross-species variation and constraining evolutionary gene expression variation.

Full Text

Duke Authors

Cited Authors

  • Cui, Q; Yu, Z; Purisima, EO; Wang, E

Published Date

  • August 2007

Published In

Volume / Issue

  • 23 / 8

Start / End Page

  • 372 - 375

PubMed ID

  • 17482307

Pubmed Central ID

  • 17482307

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2007.04.003


  • eng

Conference Location

  • England