Erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia and subsequent transformation to acute myeloid leukemia.
Journal Article (Journal Article)
Erythrophagocytosis by neutrophils is a rare phenomenon in myeloid malignancies, and its clinicopathologic significance is not fully understood. We report a unique case of erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia (CMML) and subsequent transformation to acute myeloid leukemia (AML). Review of multiple marrow samples, both pretreatment and post-treatment, demonstrated a correlation between percentage of dysplastic neutrophils and degree of erythrophagocytosis. Erythrophagocytosis was observed only in dysplastic forms of neutrophils. Post-transplant marrows with engraftment of donor cells showed no neutrophilic dysplasia or erythrophagocytosis. Possible mechanisms of neutrophilic erythrophagocytosis in myeloid malignancies are discussed.
Full Text
Duke Authors
Cited Authors
- Etzell, J; Lu, CM; Browne, LW; Wang, E
Published Date
- August 2005
Published In
Volume / Issue
- 79 / 4
Start / End Page
- 340 - 342
PubMed ID
- 16044446
International Standard Serial Number (ISSN)
- 0361-8609
Digital Object Identifier (DOI)
- 10.1002/ajh.20392
Language
- eng
Conference Location
- United States