Activities of the initial enzymes of glycerolipid and sphingolipid synthesis in lung microsomes from rats exposed to air or 85% oxygen.

Journal Article

Lungs of adult rats exposed to 85% oxygen undergo extensive cellular reorganization; therefore, to investigate changes in lipid metabolism the initial enzymes of glycerolipid and sphingolipid synthesis were measured in lung microsomes. After 1 week of O2 treatment, the specific activity of the glycerol 3-phosphate acyltransferase increased to nearly twice that of the controls and remained elevated for the 3 weeks of study. Serine palmitoyl-transferase activities were approximately the same for both groups. These results suggest that in addition to cellular proliferation caused by hyperoxia there are also selective changes in glycerolipid synthesis, which may explain the decreased sphingomyelin content of lung and lamellar bodies.

Full Text

Duke Authors

Cited Authors

  • Merrill, AH; Wang, E; Stevens, J; Brumley, GW

Published Date

  • March 30, 1984

Published In

Volume / Issue

  • 119 / 3

Start / End Page

  • 995 - 1000

PubMed ID

  • 6712682

International Standard Serial Number (ISSN)

  • 0006-291X

Language

  • eng

Conference Location

  • United States