Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.

Published

Journal Article

A series of diaryl and alkylaryl sulfoxide-containing nitrogen mustards were synthesized and evaluated for their hypoxia-selective cytotoxicity against V-79 cells in vitro as well as for their metabolism profiles with the rat S-9 fractions. In general, the diaryl sulfoxides (4, 5, and 7-9) showed much greater hypoxia selectivity (11-27-fold) than the alkylaryl sulfoxides (approximately 3-fold) (1 and 3). The fused diphenyl sulfoxides (10 and 11), on the other hand, showed very low hypoxia selectivity (1.3-3-fold). Compound 10 was highly cytotoxic under both aerobic and anaerobic conditions, while 11 showed low cytotoxicity under both conditions. The bioreduction of 8 by the rat S-9 fraction under anaerobic conditions was inhibited by menadione and enhanced by benzaldehyde, acetaldehyde, or 2-hydroxypyrimidine suggesting the involvement of aldehyde oxidase in the reduction of the sulfoxides. Bioreductive metabolism studies of selected model sulfoxides suggested that diaryl sulfoxides are better substrates for aldehyde oxidase than alkylaryl sulfoxides.

Full Text

Duke Authors

Cited Authors

  • Sun, ZY; Botros, E; Su, AD; Kim, Y; Wang, E; Baturay, NZ; Kwon, CH

Published Date

  • November 2, 2000

Published In

Volume / Issue

  • 43 / 22

Start / End Page

  • 4160 - 4168

PubMed ID

  • 11063612

Pubmed Central ID

  • 11063612

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm9904957

Language

  • eng

Conference Location

  • United States