Amperometric detection of catecholamines with liquid chromatography at a novelly constructed prussian blue chemically modified electrode.


Journal Article

A novel Prussian blue chemically modified electrode (CME) was constructed and characterized for liquid chromatography electrochemical detection (LCEC) of catecholamines. Both anodic and cathodic peaks could be obtained by monitoring at constant applied potential at anodic and slightly cathodic potential ranges (0.3-0.7 and -0.2-0.1 V vs. SCE), respectively. When arranged in a series configuration, using the modified electrodes as generating and collecting detectors, extremely high effective collection efficiencies of 0.91 (for norepinephrine) and 0.58 (for dihydroxyphenylacetic acid) were achieved in dual-electrode LCEC for catecholamines; and a linear response range over 3 orders of magnitude and a detection limit of 10 pg were obtained with a downstream CME as the indicating detector.

Full Text

Duke Authors

Cited Authors

  • Zhou, J; Wang, E

Published Date

  • March 1992

Published In

Volume / Issue

  • 39 / 3

Start / End Page

  • 235 - 242

PubMed ID

  • 18965368

Pubmed Central ID

  • 18965368

International Standard Serial Number (ISSN)

  • 0039-9140

Digital Object Identifier (DOI)

  • 10.1016/0039-9140(92)80026-a


  • eng

Conference Location

  • Netherlands