Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture.
Journal Article (Journal Article)
Human beta (fibroblast) interferon inhibits the proliferation of human HeLa-S3 carcinoma cells in suspension culture. Accompanying this effect, the lateral mobility of cell surface receptors for concanavalin A is decreased and the rigidity of the plasma membrane lipid bilayer is increased. The present findings show a marked increase in the number of polymerized actin-containing microfilaments 3 days after treatment of HeLa-S3 cells with beta-interferon (640 units/ml). The cortical region of the treated enlarged cells contains a thick and dense meshwork of 40-70 A microfilaments. The actin nature of the filaments was verified by their ability to bind heavy meromyosin. These results support the concept that beta-interferon induces a coordinated response in the plasma membrane and the underlying microfilaments in both tumor and normal cells.
Full Text
Duke Authors
Cited Authors
- Wang, E; Pfeffer, LM; Tamm, I
Published Date
- October 1, 1981
Published In
Volume / Issue
- 78 / 10
Start / End Page
- 6281 - 6285
PubMed ID
- 6171815
Pubmed Central ID
- PMC349022
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.78.10.6281
Language
- eng
Conference Location
- United States