Network motifs are enriched with transcription factors whose transcripts have short half-lives.

Journal Article (Journal Article)

Network motifs, the recurring regulatory structural patterns in networks, can self-organize to produce networks because of the large ratio of genes to transcription factors (TFs) in genomes. We find a common design principle of these motifs: the TFs whose transcripts have short half-lives are significantly enriched in motifs and hubs. This enrichment becomes one of the driving forces for the emergence of the network scale-free topology, enables the network to adapt quickly to environmental changes and mitigates gene expression fluctuations. Motifs are classified into subtypes that are preferentially used in different cellular conditions.

Full Text

Duke Authors

Cited Authors

  • Wang, E; Purisima, E

Published Date

  • September 2005

Published In

Volume / Issue

  • 21 / 9

Start / End Page

  • 492 - 495

PubMed ID

  • 16026891

International Standard Serial Number (ISSN)

  • 0168-9525

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2005.06.013


  • eng

Conference Location

  • England