Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044.

Journal Article (Journal Article)

Plasma samples from rats flown aboard COS-MOS 2044 were analyzed for the levels of key metabolites, electrolytes, enzymes, and hormones. The major differences between the flight group and the synchronous control were elevations in glucose, cholesterol, phosphate, creatinine, blood urea nitrogen, lactate dehydrogenase, and aspartate amino-transferase and decreased levels of thyroxine. Most of these differences were not mimicked by tail suspension of ground-based rats; however, both flight and suspended rats exhibited inhibited testosterone secretion. Corticosterone, immunoreactive growth hormone, and prolactin showed inconsistent differences from the various control groups, suggesting that the levels of these hormones were not due to actual or simulated microgravity.

Full Text

Duke Authors

Cited Authors

  • Merrill, AH; Wang, E; Mullins, RE; Grindeland, RE; Popova, IA

Published Date

  • August 1992

Published In

Volume / Issue

  • 73 / 2 Suppl

Start / End Page

  • 132S - 135S

PubMed ID

  • 1526939

International Standard Serial Number (ISSN)

  • 8750-7587

Digital Object Identifier (DOI)

  • 10.1152/jappl.1992.73.2.S132


  • eng

Conference Location

  • United States