Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.

Journal Article (Journal Article)

We report a case of measles inclusion-body encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5 months after measles-mumps-rubella vaccination. He had no prior evidence of immune deficiency and no history of measles exposure or clinical disease. During hospitalization, a primary immunodeficiency characterized by a profoundly depressed CD8 cell count and dysgammaglobulinemia was demonstrated. A brain biopsy revealed histopathologic features consistent with MIBE, and measles antigens were detected by immunohistochemical staining. Electron microscopy revealed inclusions characteristic of paramyxovirus nucleocapsids within neurons, oligodendroglia, and astrocytes. The presence of measles virus in the brain tissue was confirmed by reverse transcription polymerase chain reaction. The nucleotide sequence in the nucleoprotein and fusion gene regions was identical to that of the Moraten and Schwarz vaccine strains; the fusion gene differed from known genotype A wild-type viruses.

Full Text

Duke Authors

Cited Authors

  • Bitnun, A; Shannon, P; Durward, A; Rota, PA; Bellini, WJ; Graham, C; Wang, E; Ford-Jones, EL; Cox, P; Becker, L; Fearon, M; Petric, M; Tellier, R

Published Date

  • October 1999

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 855 - 861

PubMed ID

  • 10589903

International Standard Serial Number (ISSN)

  • 1058-4838

Digital Object Identifier (DOI)

  • 10.1086/520449


  • eng

Conference Location

  • United States