Measles inclusion-body encephalitis caused by the vaccine strain of measles virus.
Journal Article (Journal Article)
We report a case of measles inclusion-body encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5 months after measles-mumps-rubella vaccination. He had no prior evidence of immune deficiency and no history of measles exposure or clinical disease. During hospitalization, a primary immunodeficiency characterized by a profoundly depressed CD8 cell count and dysgammaglobulinemia was demonstrated. A brain biopsy revealed histopathologic features consistent with MIBE, and measles antigens were detected by immunohistochemical staining. Electron microscopy revealed inclusions characteristic of paramyxovirus nucleocapsids within neurons, oligodendroglia, and astrocytes. The presence of measles virus in the brain tissue was confirmed by reverse transcription polymerase chain reaction. The nucleotide sequence in the nucleoprotein and fusion gene regions was identical to that of the Moraten and Schwarz vaccine strains; the fusion gene differed from known genotype A wild-type viruses.
Full Text
Duke Authors
Cited Authors
- Bitnun, A; Shannon, P; Durward, A; Rota, PA; Bellini, WJ; Graham, C; Wang, E; Ford-Jones, EL; Cox, P; Becker, L; Fearon, M; Petric, M; Tellier, R
Published Date
- October 1999
Published In
- Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Volume / Issue
- 29 / 4
Start / End Page
- 855 - 861
PubMed ID
- 10589903
International Standard Serial Number (ISSN)
- 1058-4838
Digital Object Identifier (DOI)
- 10.1086/520449
Language
- eng
Conference Location
- United States