Transactivation of BKV and SV40 early promoters by BKV and SV40 T-antigens.


Journal Article

The early promoters of BKV and SV40 plasmids were transactivated in both BKV and SV40-transformed cells which failed to support replication of these plasmids. This suggests that the T-antigen of either virus can transactivate BKV and SV40 early promoters by either increasing the availability of cellular transcription factors or by directly interacting with specific sequences which comprise the transcriptional control region of the early promoters. We also observed that removal of 8-bp on the early side of T-antigen binding site I of BKV does not alter viral-plasmid replication.

Full Text

Duke Authors

Cited Authors

  • Caputo, A; Barbanti-Brodano, G; Wang, E; Ricciardi, RP

Published Date

  • July 1, 1986

Published In

Volume / Issue

  • 152 / 2

Start / End Page

  • 459 - 465

PubMed ID

  • 3014726

Pubmed Central ID

  • 3014726

Electronic International Standard Serial Number (EISSN)

  • 2514-4138

International Standard Serial Number (ISSN)

  • 1096-0341

Digital Object Identifier (DOI)

  • 10.1016/0042-6822(86)90148-0


  • eng