Persistence of Campylobacter fetus bacteremia associated with absence of opsonizing antibodies.

Journal Article (Journal Article)

Campylobacter fetus causes systemic infections in immunocompromised hosts. We describe a case in which C. fetus bacteremia apparently relapsed after 7 years in a patient with hypogammaglobulinemia and characterize the serum resistance of the patient's C. fetus strain and the inability of the patient's serum, with and without commercial intravenous immunoglobulin, to opsonize this and another C. fetus strain effectively. The probable presence of a sequestered site of infection in bone, the intrinsic serum resistance of the C. fetus strain, and the absence of specific antibody may account for the persistent infection in this patient. These studies suggest that intravenous immunoglobulin treatment is not useful in eradicating C. fetus bacteremia.

Full Text

Duke Authors

Cited Authors

  • Neuzil, KM; Wang, E; Haas, DW; Blaser, MJ

Published Date

  • July 1994

Published In

Volume / Issue

  • 32 / 7

Start / End Page

  • 1718 - 1720

PubMed ID

  • 7929763

Pubmed Central ID

  • PMC263773

International Standard Serial Number (ISSN)

  • 0095-1137

Digital Object Identifier (DOI)

  • 10.1128/jcm.32.7.1718-1720.1994


  • eng

Conference Location

  • United States