Urorectal septum malformation sequence.

Journal Article (Journal Article)

The urorectal septum malformation sequence consists of absent perineal and anal openings in association with ambiguous genitalia and urogenital, colonic, and lumbosacral anomalies. The full sequence is highly lethal, and the partial sequence, characterized by a single perineal opening draining a common cloaca, is compatible with life. Defects in mesodermal proliferation early in embryogenesis result in this rare condition. Timely urologic and surgical evaluations and reconstructions are imperative and necessary for survival. Urologists should be familiar with the mechanisms and presentations of this condition, as they may be involved in the diagnosis and management of such patients.

Full Text

Duke Authors

Cited Authors

  • Williams, DH; Fitchev, P; Policarpio-Nicolas, MLC; Wang, E; Brannigan, RE; Crawford, SE

Published Date

  • September 2005

Published In

Volume / Issue

  • 66 / 3

Start / End Page

  • 657 -

PubMed ID

  • 16140104

Electronic International Standard Serial Number (EISSN)

  • 1527-9995

Digital Object Identifier (DOI)

  • 10.1016/j.urology.2005.03.003


  • eng

Conference Location

  • United States