Optimal specificity and function for flexible biomolecular recognition.

Published

Journal Article

Biomolecular associations often accompanied by large conformational changes, sometimes folding and unfolding. By exploring an exactly solvable model, we constructed the free energy landscape and established a general framework for studying the biomolecular flexible binding process. We derived an optimal criterion for the specificity and function for flexible biomolecular binding where the binding and conformational folding are coupled.

Full Text

Duke Authors

Cited Authors

  • Wang, J; Xu, L; Wang, E

Published Date

  • June 15, 2007

Published In

Volume / Issue

  • 92 / 12

Start / End Page

  • L109 - L111

PubMed ID

  • 17416623

Pubmed Central ID

  • 17416623

International Standard Serial Number (ISSN)

  • 0006-3495

Digital Object Identifier (DOI)

  • 10.1529/biophysj.107.105551

Language

  • eng

Conference Location

  • United States