Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.
Journal Article (Journal Article)
The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.
Full Text
Duke Authors
Cited Authors
- Selden, JR; Emanuel, BS; Wang, E; Cannizzaro, L; Palumbo, A; Erikson, J; Nowell, PC; Rovera, G; Croce, CM
Published Date
- December 1, 1983
Published In
Volume / Issue
- 80 / 23
Start / End Page
- 7289 - 7292
PubMed ID
- 6580644
Pubmed Central ID
- PMC390040
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.80.23.7289
Language
- eng
Conference Location
- United States