Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.

Journal Article (Journal Article)

The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.

Full Text

Duke Authors

Cited Authors

  • Selden, JR; Emanuel, BS; Wang, E; Cannizzaro, L; Palumbo, A; Erikson, J; Nowell, PC; Rovera, G; Croce, CM

Published Date

  • December 1, 1983

Published In

Volume / Issue

  • 80 / 23

Start / End Page

  • 7289 - 7292

PubMed ID

  • 6580644

Pubmed Central ID

  • PMC390040

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.80.23.7289

Language

  • eng

Conference Location

  • United States