Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.
The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.
Selden, JR; Emanuel, BS; Wang, E; Cannizzaro, L; Palumbo, A; Erikson, J; Nowell, PC; Rovera, G; Croce, CM
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