Clonal persistence and evolution during a decade of recurrent melanoma.

Journal Article (Journal Article)

A patient with metastatic cutaneous melanoma responsive to immunotherapy experienced several recurrences over a decade of observation. With each recurrence, biopsies were obtained and cell lines generated. A rare mutation of the beta-catenin gene and an unbalanced methylation of the androgen receptor were documented in all cell lines. Karyotyping and comparative genomic hybridization identified consistent genetic traits in spite of divergent phenotypes, suggesting that all the metastases were derived from the same primary tumor, although they were each probably not derived from the most recent previous metastasis in a sequential manner. Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies.

Full Text

Duke Authors

Cited Authors

  • Wang, E; Voiculescu, S; Le Poole, IC; El-Gamil, M; Li, X; Sabatino, M; Robbins, PF; Nickoloff, BJ; Marincola, FM

Published Date

  • June 2006

Published In

Volume / Issue

  • 126 / 6

Start / End Page

  • 1372 - 1377

PubMed ID

  • 16470173

International Standard Serial Number (ISSN)

  • 0022-202X

Digital Object Identifier (DOI)

  • 10.1038/sj.jid.5700193


  • eng

Conference Location

  • United States