Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus.

Journal Article (Journal Article)

A series of morphological changes occurred when chick embryo fibroblasts infected with the NY68 mutant of Rous sarcoma virus were shifted from nonpermissive temperature (41degrees) to permissive temperature (37 degrees). We observed three distinct stages in cell morphology and surface topography that were correlated with a reduction in the organization and assembly of actin-containing microfilament bundles. Our observations suggest that control of microfilament organization and surface topography are responsive to the presence of a functioning transforming gene (src) product of Rous sarcoma virus.

Full Text

Duke Authors

Cited Authors

  • Wang, E; Goldberg, AR

Published Date

  • November 1, 1976

Published In

Volume / Issue

  • 73 / 11

Start / End Page

  • 4065 - 4069

PubMed ID

  • 186784

Pubmed Central ID

  • PMC431329

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.73.11.4065


  • eng

Conference Location

  • United States