Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus.
Journal Article (Journal Article)
A series of morphological changes occurred when chick embryo fibroblasts infected with the NY68 mutant of Rous sarcoma virus were shifted from nonpermissive temperature (41degrees) to permissive temperature (37 degrees). We observed three distinct stages in cell morphology and surface topography that were correlated with a reduction in the organization and assembly of actin-containing microfilament bundles. Our observations suggest that control of microfilament organization and surface topography are responsive to the presence of a functioning transforming gene (src) product of Rous sarcoma virus.
Full Text
Duke Authors
Cited Authors
- Wang, E; Goldberg, AR
Published Date
- November 1, 1976
Published In
Volume / Issue
- 73 / 11
Start / End Page
- 4065 - 4069
PubMed ID
- 186784
Pubmed Central ID
- PMC431329
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.73.11.4065
Language
- eng
Conference Location
- United States