Investigation of the influence on conformational transition of DNA induced by cationic lipid vesicles.

Journal Article (Journal Article)

Recent studies have focused on the structural features of DNA-lipid assemblies. In this paper we take nile blue A (NBA) as a probe molecule to study the influence of the conformational transition of DNA induced by didodecyldimethylammonium bromide (DDAB) cationic vesicles to the interaction between DNA and the probe molecules. We find that upon binding to DNA, a secondary conformational transition of DNA induced by the cationic liposome from the native B-form to the C-form resulted in the change of binding modes of NBA to DNA and different complexes are formed between DNA, DDAB and NBA.

Full Text

Duke Authors

Cited Authors

  • Zhang, Z; Huang, W; Wang, E; Dong, S

Published Date

  • January 15, 2003

Published In

Volume / Issue

  • 59 / 2

Start / End Page

  • 255 - 263

PubMed ID

  • 12685898

International Standard Serial Number (ISSN)

  • 1386-1425

Digital Object Identifier (DOI)

  • 10.1016/s1386-1425(02)00177-4


  • eng

Conference Location

  • England