Separation of promethazine and thioridazine using capillary electrophoresis with end-column amperometric detection.

Journal Article (Journal Article)

Promethazine and thioridazine were separated and detected by capillary electrophoresis with end-column amperometric detection. The influence of pH value on oxidation potential, the peak current and the resolution were studied and the following conditions was selected: 0.03 M Na2HPO4 and 0.015 M citric acid at pH 3.0, detection potential at 1.10 V. The detection limits of these two substances were in the range of 10(-8) mol/l. The linear range spanned two to three orders of magnitude. This method was applied to the detection of promethazine and thioridazine spiked in urine.

Full Text

Duke Authors

Cited Authors

  • Wang, R; Lu, X; Wu, M; Wang, E

Published Date

  • January 22, 1999

Published In

Volume / Issue

  • 721 / 2

Start / End Page

  • 327 - 332

PubMed ID

  • 10052707

International Standard Serial Number (ISSN)

  • 1387-2273

Digital Object Identifier (DOI)

  • 10.1016/s0378-4347(98)00485-x


  • eng

Conference Location

  • Netherlands