[Bcl-2 and bax expression in rat cerebral ischemic preconditioning].

Journal Article (English Abstract;Journal Article)

OBJECTIVE: To study the expression of apoptosis regulated genes bcl-2 and bax nocoprotein expression and its significance in rat cerebral ischemic preconditioning. METHODS: With immunohistochemical assay, bcl-2 and bax expression were studied in rat brains which were divided into four groups: the sham-operation control group, the cerebral ischemic group and the cerebral ischemic preconditioning group. RESULTS: Bcl-2 oncoprotein was induced in cerebral ischemic preconditioning control group. Bax oncoprotein expression had no obviously difference in four groups. CONCLUSIONS: The expression of bcl-2 and bax oncoprotein after sublethal ischemic preconditioning might be associated with the preconditioning protection against neuronal damage following subsequent lethal ischemia.

Full Text

Duke Authors

Cited Authors

  • Wang, E; Guo, QL; Tan, XJ

Published Date

  • June 28, 2001

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 217 - 218

PubMed ID

  • 12536685

International Standard Serial Number (ISSN)

  • 1000-5625


  • chi

Conference Location

  • China