Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick.

Published

Journal Article

The effects of feeding Fusarium moniliforme culture material, containing known concentrations of fumonisin B1 (FB1), were studied in broiler chicks. Day-old chicks were allotted randomly to dietary treatments containing 0, 1.02, 2.04, 3.06, 4.08, 5.10, 6.12, and 7.14% fumonisin culture material (FCM). These levels of FCM supplied 0, 75, 150, 225, 300, 375, 450, and 525 mg of FB1/kg of feed. Each dietary treatment was fed to four pen replicates of six birds each for 21 days. Chicks fed FCM that supplied 450 and 525 mg FB1/kg diet had lower (P < .05) feed intakes and BW gains; increased (P < .05) liver and kidney weights; and increased (P < .05) mean cell hemoglobin, and mean cell hemoglobin concentrations. Compared with controls, chicks fed FCM had increased (P < .05) free sphinganine levels and sphinganine:sphingosine ratios. Treatment-associated histological lesions were only observed in the liver of chicks fed diets containing FCM that supplied 225 mg FB1/kg or higher. Diets containing FCM that supplied levels as low as 75 mg FB1/kg affected the physiology of chicks by increasing free sphinganine levels and sphinganine:sphingosine ratios. Because inhibition of sphingolipid biosynthesis has been hypothesized as the mechanism of action of FB1, this suggests that diets containing 75 mg FB1/kg FCM may be toxic to young broiler chicks.

Full Text

Duke Authors

Cited Authors

  • Weibking, TS; Ledoux, DR; Bermudez, AJ; Turk, JR; Rottinghaus, GE; Wang, E; Merrill, AH

Published Date

  • March 1, 1993

Published In

Volume / Issue

  • 72 / 3

Start / End Page

  • 456 - 466

PubMed ID

  • 8464788

Pubmed Central ID

  • 8464788

Electronic International Standard Serial Number (EISSN)

  • 1525-3171

International Standard Serial Number (ISSN)

  • 0032-5791

Digital Object Identifier (DOI)

  • 10.3382/ps.0720456

Language

  • eng