Increases in serum sphingomyelin by 17 beta-estradiol.

Journal Article (Journal Article)

The effects of estrogens on plasma sphingomyelin and the hepatic activity of the initial enzyme of sphingomyelin synthesis were examined using immature chicks. After three days of 17 beta-estradiol administration, serum sphingomyelin, total phospholipids, and cholesterol doubled, and triacylglycerol levels increased 7.5 fold. The sphingomyelin content and percentage of total phospholipids of liver were unaffected by estrogen treatment. The specific activity of serine palmitoyltransferase (EC was unchanged, but the total activity appeared slightly higher due to increased liver weights. The higher sphingomyelin may, therefore, be due less to increased levels of biosynthetic enzymes than to factors such as the substrate (i.e., fatty acid) supply or decreased clearance of plasma sphingomyelin. These results are similar to earlier findings with key enzymes of cholesterol and glycerolipid biosynthesis and suggest that the three lipid pathways may be coordinated during estrogen treatment and enhanced very-low density lipoprotein (VLDL) synthesis.

Full Text

Duke Authors

Cited Authors

  • Merrill, AH; Wang, E; Innis, WS; Mullins, R

Published Date

  • April 1985

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 252 - 254

PubMed ID

  • 3999932

International Standard Serial Number (ISSN)

  • 0024-4201

Digital Object Identifier (DOI)

  • 10.1007/BF02534197


  • eng

Conference Location

  • United States