Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

Journal Article (Journal Article)

Beat-to-beat alternations of the cardiac monophasic action potential, known as electrical alternans, were studied at drug concentrations that have known arrhythmogenic outcomes. Electrical alternans were elicited from the heart of anesthetized guinea pigs, both in the absence and presence of drugs that inhibit the delayed rectifier K(+) channel encoded by the human ether a-go-go related-gene (HERG), and are associated with the fatal arrhythmia, Torsade de Pointes. Two other HERG inhibiting drugs not associated with Torsade de Pointes were also studied. At concentrations known to be proarrhythmic, E-4031 and bepridil increased mean alternans 10 and 40 ms at pacing frequencies

Full Text

Duke Authors

Cited Authors

  • Fossa, AA; Wisialowski, T; Wolfgang, E; Wang, E; Avery, M; Raunig, DL; Fermini, B

Published Date

  • February 20, 2004

Published In

Volume / Issue

  • 486 / 2

Start / End Page

  • 209 - 221

PubMed ID

  • 14975710

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/j.ejphar.2003.12.028


  • eng

Conference Location

  • Netherlands