The effect of unilateral electrostimulation of the subthalamic nucleus on respiratory/phonatory subsystems of speech production in Parkinson's disease--a preliminary report.

Published

Journal Article

This paper reports findings on the respiratory/phonatory subsystems from an on-going study investigating the effect of unilateral electrostimulation of the subthalamic nucleus (STN) on different speech subsystems in people with Parkinson's disease (PD). Speech recordings were made in the medication-off state at baseline, three months post surgery with stimulation-on, and with stimulation-off, in six right-handed PD patients. Subjects completed several speech tasks. Acoustic analyses of the maximally sustained vowel phonation were reported. The results were compared to the scores of the motor section of the Unified Parkinson's Disease Rating Scale (UPDRS-III) obtained under the same conditions. Results showed that stimulation-on improved UPDRS-III scores in all six subjects. While mild improvement was observed for all subjects in the Stimulation-on condition, three subjects received left-STN stimulation showed a significant decline in vocal intensity and vowel duration from their baseline indicating the speech function was very susceptible to micro lesions due to the surgical procedure itself when the surgical site was in the dominant hemisphere.

Full Text

Duke Authors

Cited Authors

  • Wang, E; Verhagen Metman, L; Bakay, R; Arzbaecher, J; Bernard, B

Published Date

  • June 2003

Published In

Volume / Issue

  • 17 / 4-5

Start / End Page

  • 283 - 289

PubMed ID

  • 12945603

Pubmed Central ID

  • 12945603

International Standard Serial Number (ISSN)

  • 0269-9206

Digital Object Identifier (DOI)

  • 10.1080/0269920031000080064

Language

  • eng

Conference Location

  • England