Melanoma-restricted genes.

Published online

Journal Article

Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted previously to characterize several variables that may affect the relationship between tumor and host immune cells but, taken one at the time, none yielded a convincing explanation. With explorative purposes, high-throughput technology was applied here to portray transcriptional characteristics unique to metastatic cutaneous melanoma that may or may not be relevant to its immunogenic potential. Several functional signatures could be identified descriptive of immune or other biological functions. In addition, the transcriptional profile of metastatic melanoma was compared with that of primary renal cell cancers (RCC) identifying several genes co-coordinately expressed by the two tumor types. Since RCC is another immune responsive tumor, commonalities between RCC and melanoma may help untangle the enigma of their potential immune responsiveness. This purely descriptive study provides, therefore, a map for the investigation of metastatic melanoma in future clinical trials and at the same time may invite consideration of novel therapeutic targets.

Full Text

Duke Authors

Cited Authors

  • Wang, E; Panelli, MC; Zavaglia, K; Mandruzzato, S; Hu, N; Taylor, PR; Seliger, B; Zanovello, P; Freedman, RS; Marincola, FM

Published Date

  • October 15, 2004

Published In

Volume / Issue

  • 2 / 1

Start / End Page

  • 34 -

PubMed ID

  • 15488140

Pubmed Central ID

  • 15488140

Electronic International Standard Serial Number (EISSN)

  • 1479-5876

Digital Object Identifier (DOI)

  • 10.1186/1479-5876-2-34


  • eng

Conference Location

  • England