Downhill kinetics of biomolecular interface binding: globally connected scenario.

Journal Article (Journal Article)

We study the kinetics of the biomolecular binding process at the interface using energy landscape theory. The global kinetic connectivity case is considered for a downhill funneled energy landscape. By solving the kinetic master equation, the kinetic time for binding is obtained and shown to have a U-shape curve-dependence on the temperature. The kinetic minimum of the binding time monotonically decreases when the ratio of the underlying energy gap between native state and average non-native states versus the roughness or the fluctuations of the landscape increases. At intermediate temperatures, fluctuations measured by the higher moments of the binding time lead to non-Poissonian, non-exponential kinetics. At both high and very low temperatures, the kinetics is nearly Poissonian and exponential.

Full Text

Duke Authors

Cited Authors

  • Wang, J; Huang, W; Lu, H; Wang, E

Published Date

  • October 2004

Published In

Volume / Issue

  • 87 / 4

Start / End Page

  • 2187 - 2194

PubMed ID

  • 15454421

Pubmed Central ID

  • PMC1304644

International Standard Serial Number (ISSN)

  • 0006-3495

Digital Object Identifier (DOI)

  • 10.1529/biophysj.104.042747

Language

  • eng

Conference Location

  • United States