Downhill kinetics of biomolecular interface binding: globally connected scenario.


Journal Article

We study the kinetics of the biomolecular binding process at the interface using energy landscape theory. The global kinetic connectivity case is considered for a downhill funneled energy landscape. By solving the kinetic master equation, the kinetic time for binding is obtained and shown to have a U-shape curve-dependence on the temperature. The kinetic minimum of the binding time monotonically decreases when the ratio of the underlying energy gap between native state and average non-native states versus the roughness or the fluctuations of the landscape increases. At intermediate temperatures, fluctuations measured by the higher moments of the binding time lead to non-Poissonian, non-exponential kinetics. At both high and very low temperatures, the kinetics is nearly Poissonian and exponential.

Full Text

Duke Authors

Cited Authors

  • Wang, J; Huang, W; Lu, H; Wang, E

Published Date

  • October 2004

Published In

Volume / Issue

  • 87 / 4

Start / End Page

  • 2187 - 2194

PubMed ID

  • 15454421

Pubmed Central ID

  • 15454421

International Standard Serial Number (ISSN)

  • 0006-3495

Digital Object Identifier (DOI)

  • 10.1529/biophysj.104.042747


  • eng

Conference Location

  • United States