Acute lymphoblastic leukaemia in childhood: cell proliferation without rest.
Journal Article (Journal Article)
The percentage of non-cycling blast cells in children with untreated acute lymphoblastic leukaemia (ALL) was investigated by staining smears for statin, a nuclear protein specifically present in non-growing resting cells. Results were compared with purified normal CD34-positive progenitors. A low fraction of ALL and CD34-positive cells expressed statin (2.9 +/- 3.8% and 2.8 +/- 3.1%, respectively), the growth fraction assessed by staining for the nucleolar antigen p120 was 94% in both ALL and CD34-positive cell samples. From this analysis it can be concluded that the compartment of non-replicating cells in ALL as well as in normal CD34-positive precursor cells collected from peripheral blood is very small and that most cells are cycling.
Full Text
Duke Authors
Cited Authors
- Hirt, A; Antic, V; Wang, E; Lüthy, AR; Leibundgut, K; von der Weid, N; Tobler, A; Wagner, HP
Published Date
- February 1997
Published In
Volume / Issue
- 96 / 2
Start / End Page
- 366 - 368
PubMed ID
- 9029026
Pubmed Central ID
- 9029026
International Standard Serial Number (ISSN)
- 0007-1048
Digital Object Identifier (DOI)
- 10.1046/j.1365-2141.1997.d01-2034.x
Language
- eng
Conference Location
- England