Acute lymphoblastic leukaemia in childhood: cell proliferation without rest.

Journal Article (Journal Article)

The percentage of non-cycling blast cells in children with untreated acute lymphoblastic leukaemia (ALL) was investigated by staining smears for statin, a nuclear protein specifically present in non-growing resting cells. Results were compared with purified normal CD34-positive progenitors. A low fraction of ALL and CD34-positive cells expressed statin (2.9 +/- 3.8% and 2.8 +/- 3.1%, respectively), the growth fraction assessed by staining for the nucleolar antigen p120 was 94% in both ALL and CD34-positive cell samples. From this analysis it can be concluded that the compartment of non-replicating cells in ALL as well as in normal CD34-positive precursor cells collected from peripheral blood is very small and that most cells are cycling.

Full Text

Duke Authors

Cited Authors

  • Hirt, A; Antic, V; Wang, E; Lüthy, AR; Leibundgut, K; von der Weid, N; Tobler, A; Wagner, HP

Published Date

  • February 1997

Published In

Volume / Issue

  • 96 / 2

Start / End Page

  • 366 - 368

PubMed ID

  • 9029026

International Standard Serial Number (ISSN)

  • 0007-1048

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.1997.d01-2034.x


  • eng

Conference Location

  • England