Effect of freeze-thawing on lipid bilayer-protected gold nanoparticles.

Journal Article (Journal Article)

In this study, varieties of lipid bilayer-protected gold nanoparticles (AuNPs) were synthesized through a simple wet chemical method, and then the effect of freeze-thawing on the as-prepared AuNPs was investigated. The freeze-thawing process induced fusion or fission of lipid bilayers tethered on the AuNPs. The UV-vis spectra and transmission electron microscopy experiments revealed that the disruption of lipid bilayer structures on the nanoparticles led to the fusion or aggregation of AuNPs. The role of freeze-thawing in the evolution of lipid bilayer-protected AuNPs was studied. The addition of adequate sucrose, a well-known cryoprotectant, effectively prevented the fusion or aggregation of lipid bilayer-protected AuNPs undergoing the freeze-thawing process. The possible mechanism of sucrose preserving the integrity of the lipid bilayer-protected AuNPs was also discussed.

Full Text

Duke Authors

Cited Authors

  • Zhang, L; Li, P; Li, D; Guo, S; Wang, E

Published Date

  • April 1, 2008

Published In

Volume / Issue

  • 24 / 7

Start / End Page

  • 3407 - 3411

PubMed ID

  • 18278967

International Standard Serial Number (ISSN)

  • 0743-7463

Digital Object Identifier (DOI)

  • 10.1021/la703737q


  • eng

Conference Location

  • United States