Prevention of fumonisin B1-induced neural tube defects by folic acid.

Published

Journal Article

BACKGROUND: The mycotoxin fumonisin B1 (FB1) inhibits sphingolipid synthesis, blocks folate transport, and has been associated with increased incidences of cancer and neural tube defects. Results from reproductive studies in animal models in vivo and in vitro have demonstrated toxicity in some cases, but no specific terata after fumonisin exposure. No information is available about folic acid's potential to protect against this toxicity. METHODS: Neurulating mouse embryos were exposed to fumonisin or folinic acid in whole embryo culture and assessed for effects on growth and development. RESULTS: Fumonisin exposure inhibited sphingolipid synthesis, reduced growth, and caused cranial neural tube defects in a dose dependent manner. Supplemental folinic acid ameliorated the effects on growth and development, but not inhibition of sphingolipid synthesis. CONCLUSION: Fumonisin has the potential to inhibit embryonic sphingolipid synthesis and to produce embryotoxicity and neural tube defects. Folic acid can reverse some of these effects, supporting results showing that fumonisin disrupts folate receptor function.

Full Text

Duke Authors

Cited Authors

  • Sadler, TW; Merrill, AH; Stevens, VL; Sullards, MC; Wang, E; Wang, P

Published Date

  • October 2002

Published In

Volume / Issue

  • 66 / 4

Start / End Page

  • 169 - 176

PubMed ID

  • 12353213

Pubmed Central ID

  • 12353213

International Standard Serial Number (ISSN)

  • 0040-3709

Digital Object Identifier (DOI)

  • 10.1002/tera.10089

Language

  • eng

Conference Location

  • United States