Preliminary study on controlled hypotension induced by nimodipine in craniocerebral surgery.


Journal Article

Nimodipine, produced in China, was applied to lower the blood pressure (BP) in 20 cases in craniocerebral operation. 0.02% solution of Nimodipine was dripped intravenously (by 0.02% of density), at a preliminary speed of 600-800 micrograms/min, and 4-12 mg of total dose. Mean arterial pressure (MAP) decreased and maintained at 7.3-8.0 kPa, and lasted 30-60 minutes. The scopes of decreasing pressure were 33.0%-37.7% of MAP, 31.6%-35.6% of systolic pressure (SP), and 36.1%-41.9% of diastolic pressure (DP). The results of lowering pressure which reduced the intraoperative bleeding were significant. After withdrawal of drug supply for 15-30 minutes, the BP raised up to the normal level. No "rebounding BP rise" occurred.

Full Text

Duke Authors

Cited Authors

  • Zhang, P; Wang, B; Wang, E; Chen, X

Published Date

  • June 1995

Published In

Volume / Issue

  • 108 / 6

Start / End Page

  • 420 - 422

PubMed ID

  • 7555250

Pubmed Central ID

  • 7555250

International Standard Serial Number (ISSN)

  • 0366-6999


  • eng

Conference Location

  • China