Preliminary study on controlled hypotension induced by nimodipine in craniocerebral surgery.

Journal Article (Clinical Trial;Journal Article)

Nimodipine, produced in China, was applied to lower the blood pressure (BP) in 20 cases in craniocerebral operation. 0.02% solution of Nimodipine was dripped intravenously (by 0.02% of density), at a preliminary speed of 600-800 micrograms/min, and 4-12 mg of total dose. Mean arterial pressure (MAP) decreased and maintained at 7.3-8.0 kPa, and lasted 30-60 minutes. The scopes of decreasing pressure were 33.0%-37.7% of MAP, 31.6%-35.6% of systolic pressure (SP), and 36.1%-41.9% of diastolic pressure (DP). The results of lowering pressure which reduced the intraoperative bleeding were significant. After withdrawal of drug supply for 15-30 minutes, the BP raised up to the normal level. No "rebounding BP rise" occurred.

Full Text

Duke Authors

Cited Authors

  • Zhang, P; Wang, B; Wang, E; Chen, X

Published Date

  • June 1995

Published In

Volume / Issue

  • 108 / 6

Start / End Page

  • 420 - 422

PubMed ID

  • 7555250

International Standard Serial Number (ISSN)

  • 0366-6999


  • eng

Conference Location

  • China