[BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit].

Published

Journal Article

Adenovirus carrying BMP-2 gene, after being mixed with fibrinous gel, was siphoned off on biodegradable scaffolds (PLA/PCL). The composite was used to repair 1.5 cm long radius defect in rabbits. Four methods were in use in the experiments: Ad-BMP-2 plus fibrinous gel and PLA/PCL (Group A), reconstructed hBMP-2 plus fibrinous gel and PLA/PCL (Group B), Ad-Lacz plus fibrinous gel and PLA/PCL (Group C), and fibrinous gel and PLA/PCL (Group D). Results showed that the defects treated in Group A were repaired with much more new bone regenerated, bridged earlier and stronger than those in Group B 12 weeks after operation. The defects treated in the other two groups could not attain osseous tissue healing. BMP-2 gene carried by biodegradable scaffold and fibrinous gel is easy to conduct and has very strong osteoinduction ability. It is really a good method to repair segmental bone defects.

Full Text

Duke Authors

Cited Authors

  • Li, J; Wang, E; Sun, H; Han, D; Wang, H; Bai, L; Li, L; Liu, X; Xu, X

Published Date

  • April 2007

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 345 - 349

PubMed ID

  • 17591257

Pubmed Central ID

  • 17591257

International Standard Serial Number (ISSN)

  • 1001-5515

Language

  • chi