Statin expression associated with terminally differentiating and postreplicative lens epithelial cells.


Journal Article

The expression of a nuclear (57 kDa) protein statin has been previously characterized as a specific marker of quiescent or senescent aging human fibroblasts in vitro. In these studies we have shown that the expression of statin is associated specifically with the postreplicative and terminally differentiating lens epithelial cell. By monitoring the synthesis of specific lens crystallin proteins, and the morphological and cellular changes associated with this differentiated system, we have demonstrated a close correlation between statin expression and cell commitment to the G0 nonreplicative cell cycle state.

Full Text

Duke Authors

Cited Authors

  • Muggleton-Harris, AL; Wang, E

Published Date

  • May 1989

Published In

Volume / Issue

  • 182 / 1

Start / End Page

  • 152 - 159

PubMed ID

  • 2653851

Pubmed Central ID

  • 2653851

International Standard Serial Number (ISSN)

  • 0014-4827

Digital Object Identifier (DOI)

  • 10.1016/0014-4827(89)90287-5


  • eng

Conference Location

  • United States