Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets.

Published

Journal Article

Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and inducing immune regulatory mechanisms on the other. This complexity results from a cross talk among immune cells which sways the effects of IL-2 according to the experimental or clinical condition tested. Recombinant IL-2 (rIL-2) stimulation of peripheral blood mononuclear cells (PBMC) from 47 donors of different genetic background induced generalized T cell activation and anti-apoptotic effects. Most effects were dependent upon interactions among immune cells. Specialized functions of CD4 and CD8 T cells were less dependent upon and often dampened by the presence of other PBMC populations. In particular, cytotoxic T cell effector function was variably affected with a component strictly dependent upon the direct stimulation of CD8 T cells in the absence of other PBMC. This observation may provide a roadmap for the interpretation of the discrepant biological activities of rIL-2 observed in distinct pathological conditions or treatment modalities.

Full Text

Duke Authors

Cited Authors

  • Jin, P; Wang, E; Provenzano, M; Deola, S; Selleri, S; Ren, J; Voiculescu, S; Stroncek, D; Panelli, MC; Marincola, FM

Published Date

  • January 2006

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 26 -

PubMed ID

  • 16805915

Pubmed Central ID

  • 16805915

Electronic International Standard Serial Number (EISSN)

  • 1479-5876

International Standard Serial Number (ISSN)

  • 1479-5876

Digital Object Identifier (DOI)

  • 10.1186/1479-5876-4-26

Language

  • eng