Autoregulation of Tcr V region epitopes in autoimmune disease.

Published

Journal Article

Normal individuals possess low levels of autoantibodies specific for certain peptide defined regions of T-cell receptor (Tcr) variable regions, particularly CDR1 and Fr3. These regions are predicted to be exposed on the surface of the native molecule and, by analogy and comparison with immunoglobulins, correspond to public idiotype determinants. The anti-Tcr idiotype antibodies appear to be ubiquitous and we propose that they play a role in the regulation of T-cell function. To delineate the parameters of expression of these antibodies, we characterized anti-Tcr antibody activity in normal individuals, in those suffering from the autoimmune diseases rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and in patients with non-autoimmune arthritis (osteoarthritis) as a disease control. There were significant increases in autoantibody levels in the autoimmune patients. There was also variation in isotype and the particular variable regions recognized. IgM autoantibodies directed against a few peptide defined determinants were elevated in RA, whereas SLE patient sera showed high levels of IgG binding to a broad spectrum of Tcr peptides.

Full Text

Duke Authors

Cited Authors

  • Schluter, SF; Wang, E; Winfield, JB; Yocum, DE; Marchalonis, JJ

Published Date

  • 1995

Published In

Volume / Issue

  • 383 /

Start / End Page

  • 231 - 236

PubMed ID

  • 8644507

Pubmed Central ID

  • 8644507

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-1-4615-1891-4_24

Language

  • eng

Conference Location

  • United States