The dual role of IL-10.

Journal Article (Journal Article;Review)

Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability. In addition, by inhibiting the maturation of antigen-presenting cells (APCs), IL-10 preserves their ability for antigen uptake while simultaneously hampering their migration to draining lymph nodes. This review suggests that this "antigen-loading" phase might constitute an important component of the innate immune reaction to a pathogen. Additional proinflammatory stimuli might subsequently lead to maturation of "loaded" APCs that could migrate to draining lymph nodes or recruit and activate adaptive immune effectors locally.

Full Text

Duke Authors

Cited Authors

  • Mocellin, S; Panelli, MC; Wang, E; Nagorsen, D; Marincola, FM

Published Date

  • January 2003

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 36 - 43

PubMed ID

  • 12495723

International Standard Serial Number (ISSN)

  • 1471-4906

Digital Object Identifier (DOI)

  • 10.1016/s1471-4906(02)00009-1


  • eng

Conference Location

  • England