Robustness, dissipations and coherence of the oscillation of circadian clock: potential landscape and flux perspectives.
Published online
Journal Article
Finding the global probabilistic nature of a non-equilibrium circadian clock is essential for addressing important issues of robustness and function. We have uncovered the underlying potential energy landscape of a simple cyanobacteria biochemical network, and the corresponding flux which is the driving force for the oscillation. We found that the underlying potential landscape for the oscillation in the presence of small statistical fluctuations is like an explicit ring valley or doughnut shape in the three dimensional protein concentration space. We found that the barrier height separating the oscillation ring and other area is a quantitative measure of the oscillation robustness and decreases when the fluctuations increase. We also found that the entropy production rate characterizing the dissipation or heat loss decreases as the fluctuations decrease. In addition, we found that, as the fluctuations increase, the period and the amplitude of the oscillations is more dispersed, and the phase coherence decreases. We also found that the properties from exploring the effects of the inherent chemical rate parameters on the robustness. Our approach is quite general and can be applied to other oscillatory cellular network.PACS Codes: 87.18.-h, 87.18.Vf, 87.18.Yt.
Full Text
Duke Authors
Cited Authors
- Wang, J; Xu, L; Wang, E
Published Date
- December 30, 2008
Published In
Volume / Issue
- 1 / 1
Start / End Page
- 7 -
PubMed ID
- 19351381
Pubmed Central ID
- 19351381
Electronic International Standard Serial Number (EISSN)
- 1757-5036
Digital Object Identifier (DOI)
- 10.1186/1757-5036-1-7
Language
- eng
Conference Location
- England