Pediatric antifungal agents.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: In immunocompromised hosts, invasive fungal infections are common and fatal. In the past decade, the antifungal armamentarium against invasive mycoses has expanded greatly. The purpose of the present report is to review the most recent literature addressing the use of antifungal agents in children. RECENT FINDINGS: Most studies evaluating the safety and efficacy of antifungal agents are limited to adults. However, important progress has been made in describing the pharmacokinetics and safety of newer antifungal agents in children, including the echinocandins. SUMMARY: Dosage guidelines for newer antifungal agents are currently based on adult and limited pediatric data. Because important developmental pharmacology changes occur throughout childhood impacting the pharmacokinetics of these agents, antifungal studies specifically designed for children are necessary.

Full Text

Duke Authors

Cited Authors

  • Cohen-Wolkowiez, M; Moran, C; Benjamin, DK; Smith, PB

Published Date

  • December 2009

Published In

Volume / Issue

  • 22 / 6

Start / End Page

  • 553 - 558

PubMed ID

  • 19741525

Pubmed Central ID

  • PMC2776826

Electronic International Standard Serial Number (EISSN)

  • 1473-6527

Digital Object Identifier (DOI)

  • 10.1097/QCO.0b013e3283321ccc


  • eng

Conference Location

  • United States