Skip to main content

Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure.

Publication ,  Journal Article
McCrindle, BW; Zak, V; Sleeper, LA; Paridon, SM; Colan, SD; Geva, T; Mahony, L; Li, JS; Breitbart, RE; Margossian, R; Williams, RV; Atz, AM ...
Published in: Circulation
January 5, 2010

BACKGROUND: Patients after the Fontan procedure are at risk for suboptimal functional health status, and associations with laboratory measures are important for planning interventions and outcome measures for clinical trials. METHODS AND RESULTS: Parents completed the generic Child Health Questionnaire for 511 Fontan Cross-Sectional Study patients 6 to 18 years of age (61% male). Associations of Child Health Questionnaire Physical and Psychosocial Functioning Summary Scores (FSS) with standardized measurements from prospective exercise testing, echocardiography, magnetic resonance imaging, and measurement of brain natriuretic peptide were determined by regression analyses. For exercise variables for maximal effort patients only, the final model showed that higher Physical FSS was associated only with higher maximum work rate, accounting for 9% of variation in Physical FSS. For echocardiography, lower Tei index (particularly for patients with extracardiac lateral tunnel connections), lower indexed end-systolic volume, and the absence of atrioventricular valve regurgitation for patients having Fontan procedure at age <2 years were associated with higher Physical FSS, accounting for 14% of variation in Physical FSS. For magnetic resonance imaging, ratio of lower mass to end-diastolic volume and midquartiles of indexed end-systolic volume (nonlinear) were associated with higher Physical FSS, accounting for 11% of variation. Lower brain natriuretic peptide was significantly but weakly associated with higher Physical FSS (1% of variation). Significant associations for Psychosocial FSS with laboratory measures were fewer and weaker than for Physical FSS. CONCLUSIONS: In relatively healthy Fontan patients, laboratory measures account for a small proportion of the variation in functional health status and therefore may not be optimal surrogate end points for trials of therapeutic interventions.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

January 5, 2010

Volume

121

Issue

1

Start / End Page

34 / 42

Location

United States

Related Subject Headings

  • Ventricular Dysfunction
  • Surveys and Questionnaires
  • Postoperative Complications
  • Natriuretic Peptide, Brain
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Heart Defects, Congenital
  • Health Status
  • Fontan Procedure
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McCrindle, B. W., Zak, V., Sleeper, L. A., Paridon, S. M., Colan, S. D., Geva, T., … Pediatric Heart Network Investigators, . (2010). Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure. Circulation, 121(1), 34–42. https://doi.org/10.1161/CIRCULATIONAHA.109.869396
McCrindle, Brian W., Victor Zak, Lynn A. Sleeper, Stephen M. Paridon, Steven D. Colan, Tal Geva, Lynn Mahony, et al. “Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure.Circulation 121, no. 1 (January 5, 2010): 34–42. https://doi.org/10.1161/CIRCULATIONAHA.109.869396.
McCrindle BW, Zak V, Sleeper LA, Paridon SM, Colan SD, Geva T, et al. Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure. Circulation. 2010 Jan 5;121(1):34–42.
McCrindle, Brian W., et al. “Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure.Circulation, vol. 121, no. 1, Jan. 2010, pp. 34–42. Pubmed, doi:10.1161/CIRCULATIONAHA.109.869396.
McCrindle BW, Zak V, Sleeper LA, Paridon SM, Colan SD, Geva T, Mahony L, Li JS, Breitbart RE, Margossian R, Williams RV, Gersony WM, Atz AM, Pediatric Heart Network Investigators. Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure. Circulation. 2010 Jan 5;121(1):34–42.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

January 5, 2010

Volume

121

Issue

1

Start / End Page

34 / 42

Location

United States

Related Subject Headings

  • Ventricular Dysfunction
  • Surveys and Questionnaires
  • Postoperative Complications
  • Natriuretic Peptide, Brain
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Heart Defects, Congenital
  • Health Status
  • Fontan Procedure