Anti-HIV-1 ADCC: clinical and therapeutic implications.

Published

Journal Article (Review)

The predominant antienvelope cell-mediated cytotoxicity in HIV-1-infected patients is a direct form of antibody-dependent cellular cytotoxicity (ADCC) in which circulating NK/K cells armed with cytophilic antibodies comprise a cytolytic effector cell complex capable of destroying HIV-1-expressing targets. This non-MHC-restricted form of virus-specific cytotoxicity is present in most infected patients, with maximum activity in early disease, gradually declining with disease progression. This endogenous cytotoxicity provides a focal point in the design of interventive strategies involving immune-based therapies. In the first such attempts, the lymphokine interleukin-2 has been employed in an effort to augment these potentially beneficial cytolytic reactivities. The focus of this article is to present the rationale, early clinical results, and future direction of such therapeutic approaches and, in doing so, to illustrate how careful basic research findings can be applied to the design of rational therapeutic strategies.

Full Text

Duke Authors

Cited Authors

  • Weinhold, KJ

Published Date

  • 1991

Published In

Volume / Issue

  • 2 / 1-2

Start / End Page

  • 147 - 157

PubMed ID

  • 1845118

Pubmed Central ID

  • 1845118

International Standard Serial Number (ISSN)

  • 0898-2848

Language

  • eng

Conference Location

  • United States