Transmission of HIV by antigen presenting cells during T-cell activation: prevention by 3'-azido-3'-deoxythymidine.
Journal Article (Journal Article)
Tetanus toxoid (TT) reactive CD4+ cells were infected with HTLV-IIIB and exposed to TT at various times throughout a 7-day interval. Acute infection per se failed to produce overt cytopathology. However, exposure of infected cells to TT resulted in a rapid loss of cell viability, an increase in viral p24 expression, and a decline in T-cell blastogenesis. To determine whether HIV infection of antigen presenting cells (APC) could impact on T-cell activation, virus infected APC were utilized to present TT to responsive CD4+ cells. Use of infected APC produced effects similar to antigen stimulation of infected T-cells. These results suggest that the conditions of antigen presentation during T-cell activation may provide an excellent opportunity for virus transmission which may produce maximal immune dysfunction. However, preincubating antigen specific T-cells with the virostatic agent 3'-azido-3'-deoxythymidine (AZT) could prevent most of these effects.
Full Text
Duke Authors
Cited Authors
- Lyerly, HK; Cohen, OJ; Weinhold, KJ
Published Date
- 1987
Published In
Volume / Issue
- 3 / 1
Start / End Page
- 87 - 94
PubMed ID
- 3497654
International Standard Serial Number (ISSN)
- 0889-2229
Digital Object Identifier (DOI)
- 10.1089/aid.1987.3.87
Language
- eng
Conference Location
- United States