Murine in vitro antigenic modification of tumor cells: effect on susceptibility to natural cell-mediated cytotoxicity.

Journal Article (Journal Article)

A 3-methylcholanthrene [(MCA) CAS: 56-49-5]-induced fibrosarcoma cell line and its Friend murine leukemia virus-infected counterpart were assessed for their susceptibility to lysis by so-called "natural" effector cells in a series of 51Cr release assays. Detailed functional and phenotypic analysis of lytic effector cell populations from normal C57BL/6 mouse spleens revealed an identity most closely associated with natural cytotoxic cells. Neither tumor cell line was found to be sensitive to natural killer-mediated lysis. Additionally, virus infection of the MCA-induced fibrosarcoma cell line did not affect susceptibility to natural cell-mediated cytotoxicity.

Full Text

Duke Authors

Cited Authors

  • Langweiler, M; Weinhold, KJ; Matthews, TJ; Bolognesi, DP

Published Date

  • March 1, 1985

Published In

Volume / Issue

  • 74 / 3

Start / End Page

  • 699 - 704

PubMed ID

  • 2983140

International Standard Serial Number (ISSN)

  • 0027-8874


  • eng

Conference Location

  • United States