Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.
Currently available anti-human immunodeficiency virus type 1 (HIV-1) agents such as azidothymidine can prevent de novo virus infection in vitro but lack significant activity against chronically infected cells. Our laboratory has recently described glycoprotein (gp)120-specific cell mediated cytotoxicity (CMC) present in HIV-1-seropositive individuals that is capable of destroying virally infected cells. As a means of potentially eliminating persistent reservoirs of HIV-1, we examined the ability of various cytokines to augment preexisting gp120-specific CMC activity of peripheral blood mononuclear cells obtained from early disease patients. We found that interferon-gamma alone had no effect on gp120 cellular reactivity; however, the combination of interferon-gamma plus IL-2 produced enhancement beyond that of IL-2 alone.
Duke Scholars
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- Tumor Cells, Cultured
- Killer Cells, Natural
- Interleukin-2
- Interferon-gamma
- Humans
- HIV-1
- HIV Envelope Protein gp120
- Cytotoxicity, Immunologic
- Cytokines
- Biological Factors
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Cells, Cultured
- Killer Cells, Natural
- Interleukin-2
- Interferon-gamma
- Humans
- HIV-1
- HIV Envelope Protein gp120
- Cytotoxicity, Immunologic
- Cytokines
- Biological Factors