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Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.

Publication ,  Journal Article
Stine, KC; Bolognesi, D; Weinhold, KJ
Published in: J Biol Response Mod
October 1989

Currently available anti-human immunodeficiency virus type 1 (HIV-1) agents such as azidothymidine can prevent de novo virus infection in vitro but lack significant activity against chronically infected cells. Our laboratory has recently described glycoprotein (gp)120-specific cell mediated cytotoxicity (CMC) present in HIV-1-seropositive individuals that is capable of destroying virally infected cells. As a means of potentially eliminating persistent reservoirs of HIV-1, we examined the ability of various cytokines to augment preexisting gp120-specific CMC activity of peripheral blood mononuclear cells obtained from early disease patients. We found that interferon-gamma alone had no effect on gp120 cellular reactivity; however, the combination of interferon-gamma plus IL-2 produced enhancement beyond that of IL-2 alone.

Duke Scholars

Published In

J Biol Response Mod

ISSN

0732-6580

Publication Date

October 1989

Volume

8

Issue

5

Start / End Page

501 / 510

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Killer Cells, Natural
  • Interleukin-2
  • Interferon-gamma
  • Humans
  • HIV-1
  • HIV Envelope Protein gp120
  • Cytotoxicity, Immunologic
  • Cytokines
  • Biological Factors
 

Citation

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ICMJE
MLA
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Stine, K. C., Bolognesi, D., & Weinhold, K. J. (1989). Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity. J Biol Response Mod, 8(5), 501–510.
Stine, K. C., D. Bolognesi, and K. J. Weinhold. “Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.J Biol Response Mod 8, no. 5 (October 1989): 501–10.
Stine KC, Bolognesi D, Weinhold KJ. Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity. J Biol Response Mod. 1989 Oct;8(5):501–10.
Stine, K. C., et al. “Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity.J Biol Response Mod, vol. 8, no. 5, Oct. 1989, pp. 501–10.
Stine KC, Bolognesi D, Weinhold KJ. Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity. J Biol Response Mod. 1989 Oct;8(5):501–510.

Published In

J Biol Response Mod

ISSN

0732-6580

Publication Date

October 1989

Volume

8

Issue

5

Start / End Page

501 / 510

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Killer Cells, Natural
  • Interleukin-2
  • Interferon-gamma
  • Humans
  • HIV-1
  • HIV Envelope Protein gp120
  • Cytotoxicity, Immunologic
  • Cytokines
  • Biological Factors