The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic retrovirus-producing cells from the bone marrow of leukemia-prone AKR mice.
Published
Journal Article
Ecotropic virus-producing cells in the bone marrow of the leukemia-prone AKR strain of mice were significantly enriched by fractionation on discontinuous density gradients of Percoll and were found in a low-density population of cells comprised predominantly of medium to large blast cells. The high ecotropic virus-producing low-density bone marrow cell population was also found to be significantly enriched in pluripotent stem cells, prothymocytes, and stromal elements. During the period of time defined by a window for successful leukemosuppressive immunotherapy of AKR mice, virus-producing cells were exclusively detected in this fraction of bone marrow cells, implicating the functional classes of cells coenriched in this fraction as both potential targets of anti-viral immunotherapy and responsible for the seeding of the spleen and thymus with infectious ecotropic virus.
Full Text
Duke Authors
Cited Authors
- Buckheit, RW; Kurtzberg, J; Bolognesi, DP; Weinhold, KJ
Published Date
- February 1, 1988
Published In
Volume / Issue
- 162 / 2
Start / End Page
- 354 - 361
PubMed ID
- 2829423
Pubmed Central ID
- 2829423
International Standard Serial Number (ISSN)
- 0042-6822
Digital Object Identifier (DOI)
- 10.1016/0042-6822(88)90475-8
Language
- eng
Conference Location
- United States