Cellular anti-GP120 cytolytic reactivities in HIV-1 seropositive individuals.

Published

Journal Article

Forty-one patients seropositive for human immunodeficiency virus type 1 (HIV-1) were assessed for cell-mediated cytotoxicity (CMC) against autologous target cells bearing the major envelope glycoprotein of HIV-1, gp120. Effector lymphocytes from over 85% of seropositive patients showed CMC specific for gp120-coated targets, whereas seronegative individuals had no detectable CMC. As a group, symptomless individuals had the highest levels of CMC; patients with AIDS-related complex and AIDS showed progressively diminished reactivity. The gp120-specific CMC was mediated by a population of non-T-cell effectors phenotypically resembling NK/K cells. Cytolysis was not restricted by major histocompatibility complex determinants, as shown by killing of heterologous gp120-adsorbed targets and of HIV-1-infected cell-lines. Gp120-specific CMC was highly augmented in the presence of interleukin 2, so it may be possible to develop therapeutic strategies aimed at destruction of virus-producing cell reservoirs in infected individuals through stimulation of HIV-specific host CMC.

Full Text

Duke Authors

Cited Authors

  • Weinhold, KJ; Lyerly, HK; Matthews, TJ; Tyler, DS; Ahearne, PM; Stine, KC; Langlois, AJ; Durack, DT; Bolognesi, DP

Published Date

  • April 23, 1988

Published In

Volume / Issue

  • 1 / 8591

Start / End Page

  • 902 - 905

PubMed ID

  • 2895830

Pubmed Central ID

  • 2895830

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/s0140-6736(88)91713-8

Language

  • eng

Conference Location

  • England