The effects of leukemosuppressive immunotherapy on thymic infectious cell centers in AKR mice.
Although cortical thymocytes were found to be the predominant ecotropic and MCF-virus producers in the thymus of leukemia prone AKR mice the initial ecotropic retrovirus producing cells have been detected among a low density subpopulation of thymocytes including both PNA(+) and PNA(-) cells. Leukemosuppressive anti-viral treatment of these animals results in several important changes in the AKR thymus, including the elimination of virus producing cells, the induction of cellular phenotypic alterations, a decreased ability to bind ecotropic and MCF virus, a resistance to challenge with leukemogenic exogenous retroviruses, and the apparent elimination of a population of virus producing radioresistant cells. In addition, complement-mediated depletion with anti-viral IgG resulted in the complete elimination of proliferating thymocytes. These results suggest that passive anti-viral immunotherapy effectively eliminates a population of thymocytes which serve as the neonatal source of endogenous retroviruses and interferes with the earliest stages of leukemogenesis in AKR mice.
Duke Scholars
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Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Mice, Inbred AKR
- Mice
- Lymphocyte Activation
- Leukemia, Experimental
- Immunotherapy
- Immunoglobulin G
- Friend murine leukemia virus
- Cytotoxicity, Immunologic
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Thymus Gland
- T-Lymphocytes
- Mice, Inbred AKR
- Mice
- Lymphocyte Activation
- Leukemia, Experimental
- Immunotherapy
- Immunoglobulin G
- Friend murine leukemia virus
- Cytotoxicity, Immunologic