The effects of leukemosuppressive immunotherapy on thymic infectious cell centers in AKR mice.
Journal Article (Journal Article)
Although cortical thymocytes were found to be the predominant ecotropic and MCF-virus producers in the thymus of leukemia prone AKR mice the initial ecotropic retrovirus producing cells have been detected among a low density subpopulation of thymocytes including both PNA(+) and PNA(-) cells. Leukemosuppressive anti-viral treatment of these animals results in several important changes in the AKR thymus, including the elimination of virus producing cells, the induction of cellular phenotypic alterations, a decreased ability to bind ecotropic and MCF virus, a resistance to challenge with leukemogenic exogenous retroviruses, and the apparent elimination of a population of virus producing radioresistant cells. In addition, complement-mediated depletion with anti-viral IgG resulted in the complete elimination of proliferating thymocytes. These results suggest that passive anti-viral immunotherapy effectively eliminates a population of thymocytes which serve as the neonatal source of endogenous retroviruses and interferes with the earliest stages of leukemogenesis in AKR mice.
Full Text
Duke Authors
Cited Authors
- Buckheit, RW; Liberman, SN; Bolognesi, DP; Weinhold, KJ
Published Date
- 1988
Published In
Volume / Issue
- 12 / 3
Start / End Page
- 143 - 156
PubMed ID
- 3266951
International Standard Serial Number (ISSN)
- 0165-6090
Language
- eng
Conference Location
- Netherlands