Comparison of anti-HIV-1 ADCC reactivities in infected humans and chimpanzees.

Published

Journal Article

Despite its shortcomings as a disease model, the chimpanzee is still the most relevant animal model for human immunodeficiency virus type 1 (HIV-1) infection. Previous studies have revealed qualitative differences between human and chimpanzee anti-HIV-1 responses. In this study, the development of specific anti-HIV-1 antibody-dependent cellular cytotoxic (ADCC) reactivities was evaluated in chronically infected chimpanzees and compared to the human response, because anti-HIV-1 ADCC represents a major component of anti-envelope cytolytic response found in infected patients. Ten HIV-1-infected chimpanzees up to 5 years after the infection were investigated. Anti-HIV-1 ADCC-directing antibodies were detectable in only three of 10 infected chimpanzees, and in these animals, activity was apparent only several months after the HIV infection. In some of the infected animals, ADCC reactivity against infected cells preceded reactivity against gp120-coated targets. When anti-gp120 ADCC-directing antibodies were apparent, they exhibited the same broad reactivity described in humans against different HIV isolates. The pattern of ADCC reactivities in infected chimpanzees is completely different from the well-characterized anti-gp120 cytotoxic reactivities present in HIV-1-infected patients. It is a relatively rare and late-occurring event that may have an important bearing on the lack of virus-induced pathogenesis in the chimpanzee model.

Full Text

Duke Authors

Cited Authors

  • Ferrari, G; Place, CA; Ahearne, PM; Nigida, SM; Arthur, LO; Bolognesi, DP; Weinhold, KJ

Published Date

  • April 1, 1994

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 325 - 331

PubMed ID

  • 8133445

Pubmed Central ID

  • 8133445

International Standard Serial Number (ISSN)

  • 0894-9255

Language

  • eng

Conference Location

  • United States